A man in his 30s suffered serious injuries and had to be treated at the scene before paramedics could rush him to hospital for further aid.
An ambulance, air ambulance and a paramedic in a response vehicle all attended the scene.
A man, also in his 30s, has now been charged with attempted murder, officers have confirmed.
The incident is under both a criminal investigation, according to the force and the trust which runs the unit.
A spokesperson for Greater Manchester Police has said: “Police were called shortly after midday (Wednesday 27 October) to a report of a stabbing at Park House, Manchester.
“A man in his 30s suffered serious injuries but is now in a stable condition.
“A second man in his 30s has been charged with attempted murder.
“This was believed to be a contained incident and GMP are working with staff at North Manchester General Hospital to investigate the circumstances.”
Park House is operated by Greater Manchester Mental Health Trust, and includes eight wards.
The wards hold a range of patients, with both male and female acute wards; a male psychiatric intensive care unit; an all-male rehabilitation unit; and a female later life ward.
A spokesperson for the trust told the Manchester Evening News : “We can confirm an incident occurred at the Park House unit of North Manchester General Hospital on 27 October 2021.
“We are cooperating fully with Greater Manchester Police’s investigation.
“It would be inappropriate for the Trust to comment further at this time.”
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Source: Manchester Evening News, 19th November 2021